Among men, ORs for pancreatic cancer increased with increasing duration and increasing dose of heavy alcohol consumption (all p-trend < 0.04, Table 2). Relative to never or infrequent drinkers, men with the highest lifetime alcohol consumption had a greater than twofold increased risk of pancreatic cancer that remained elevated when assessment of alcohol consumption was limited to the past 20 years (Table 2). Risk was elevated regardless of when in the past the heavy consumption had occurred; ORs ranged from 2 to 2.6 for heavy drinking in the past 10, 20, or 30 years (data not shown). When analyses were restricted to the heaviest drinkers, results showed that risk increased with increasing decades of heavy consumption (>21 drinks/week p-trend = 0.02, >35 drinks/week p-trend = 0.01, Table 2).
