Third, we explicitly modelled how changes in modifiable risk factors, such as SBP and BMI, can compensate for high genomic risk. Previous research has demonstrated that intervening on modifiable risk factors can compensate for increased genetic risk of disease21,37. However, these analyses relied on simply counting the number of elevated risk factors, which does not account for the differences in effect size between various risk factors. Importantly, our approach was flexible in that various combinations of risk factor reductions can lead to the same outcome in terms of risk.
