Second, the IS metaGRS had comparable predictive power to SBP, higher predictive power than other established risk factors measured, apart from hypertension, and captured residual risk not quantified by the established risk factors. In anticipation of a potential role in early screening, we estimate the risk reduction through modifiable stroke risk factors across different metaGRS backgrounds, and further show that current guidelines for stroke risk factors may be insufficiently stringent for individuals at high metaGRS.
