Finally, KCNT2 encodes a potassium voltage-gated channel (subfamily S, member 2). The sodium-activated potassium channels Slack and Slick are encoded by KCNT1 (potassium channel, subfamily T, member 1) and KCNT2, respectively, which are found in neurons throughout the brain. Suggestive association for SNPs near KCNT2 have previously been found for cocaine dependence and for early-onset, highly comorbid, heavy opioid use.63, 64 This suggests that potassium signaling may have a role in addiction.
