Schizophrenia-like psychosis of epilepsy (SLPE) is a neuropsychiatric disorder that clinically closely resembles schizophrenia with a typical presentation as a paranoid-hallucinatory syndrome along with other psychopathological disturbances and cognitive deficits. However, compared with schizophrenia, SLPE distinguishes itself by a relative absence of negative symptoms, lesser severity, and better premorbid as well as long-term functioning [9], [10]. Several neuroimaging studies looking at localized structural and functional abnormalities at rest and during cognitive tasks in SLPE have revealed subtle or prominent cortical pathology and cerebral dysfunction mainly localized to temporal and frontal regions [11]–[14]. For instance, in a recent study using magnetoencephalography, we found working memory-related dysfunction localized to the prefrontal and left temporal cortex in patients with SLPE [15], with the activity in the prefrontal cortex correlating with psychopathological measures [16]. Others have noticed white matter structural abnormalities in SLPE using diffusion tensor imaging [17]. This suggests that like in schizophrenia, in addition to gray matter deficits and cortical dysfunction, white matter pathology and disrupted connections between brain areas may also play a role in the pathophysiology of SLPE. In support
