diffusion tensor imaging [17]. This suggests that like in schizophrenia, in addition to gray matter deficits and cortical dysfunction, white matter pathology and disrupted connections between brain areas may also play a role in the pathophysiology of SLPE. In support to this view, there is evidence that a number of diseases of the white matter such as leukodystrophies, neoplasms, inflammatory diseases, and callosal anomalies can present as a schizophrenia-like disorder [18]. However, to date, no attempt has been made to determine abnormal patterns of functional connectivity in SLPE either in resting state or during performance of cognitive tasks.
