Chunk #24 — RESULTS — DNA Resequencing in the CHRNA5 and CHRNA3 intergenic region

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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Table 3 shows association results for these 11 SNPs. Three SNPs were highly correlated with already genotyped SNPs (r2 > 0.9) and did not provide new information. The most significant novel SNP, GSC3-26, had a relatively strong odds ratio of 0.67 (0.50–0.89) and an r2 ≤ 0.25 with previously genotyped SNPs, though |D′| was often high (e.g. r2 = 0.23, |D′| = 1.0 with rs3743078).