Chunk #25 — RESULTS — DNA Resequencing in the CHRNA5 and CHRNA3 intergenic region

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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We therefore genotyped GSC3_26 in the remaining EAs and AAs (Tables 1 and 2). GSC3_26 is relatively uncommon (MAF of 0.062 in EAs and 0.014 in AAs). In the combined sample with race and gender as covariates, p = 0.032, OR = 0.76 (0.59–0.97).