Chunk #26 — RESULTS — LD and cross-population heterogeneity

Source

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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Figure 1 displays EA and AA results and r2 for all 76 SNPs. The LD results confirm that the most significantly associated SNPs in the full sample are highly correlated with rs16969968 in EAs (r2 ranging from 0.68 to 1.00). These SNPs all have OR > 1. In AAs, the LD is reduced (r2 from 0.11 to 0.73). The next group of significantly associated SNPs, which have OR < 1, are highly correlated with rs578776 in EAs.