Chunk #27 — RESULTS — LD and cross-population heterogeneity

Source

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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yes

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Three SNPs are of particular interest from the single-SNP association results: rs16969968 (associated in both EAs and AAs); rs555018 (associated in AAs only), and rs578776 (associated in EAs only). Among them, r2 is low to moderate; |D′| is higher. For rs16969968 and rs555018, r2 is 0.39 and |D′| = 0.99 in EAs, while r2 = 0.024 and |D′| = 1 in AAs. For rs16969968 and rs578776, r2 = 0.20 and |D′| = 1 in EAs; r2 = 0.07 and |D′| = 1 in AAs. For rs555018 and rs578776, r2 = 0.075 and |D′| = 0.52 in EAs; r2 = 0.43 and |D′| = 0.90 in AAs.