measurement error into the analysis (and hence decrease heritability estimates). Our results strongly suggest that reanalysis using a more precise definition of eczema would result in a cleaner phenotype and consequently increase the number of genome-wide significant loci detected. Table 2.SNP heritability for atopic dermatitisType of Heritability ScaleH2SE_H2λGCMean χ2InterceptObserved Scale (no filaggrin)0.0710.0161.0531.0801.034Liability Scale (no filaggrin)0.0780.0181.0531.0801.034Observed Scale (with filaggrin)0.0730.0181.0541.0831.034Liability Scale (with filaggrin)0.0970.0201.0541.0831.034H2 and SE_H2 refer to the SNP heritability and standard error of the SNP heritability.
