Spectral analysis applied in our studies allowed association of low frequency power bands delta and theta activity with the early development of convulsant activity within the limbic system following exposure to DOM. The EEG events preceded motoric seizures. The FFT –processed ECoG successfully measured increases in delta and theta that were below the threshold of voltage or duration required to induce seizure-related behaviors. The enhancement of spectral power observed in low frequency bands after the ibogaine/cocaine treatment indicating lower threshold for seizures was somehow contradictory to the noncompetitive NMDA receptor antagonist properties of ibogaine. However, ibogaine, like another NMDA antagonist, MK-801, stimulates corticosterone release that has been shown to increase susceptibility to seizures.
