The ECoG findings of a deficit in slow-wave brain activity after repeated exposure to cocaine confirmed observations in human subjects where addiction to cocaine was associated with deficits in delta power combined with reduced blood flow in the prefrontal cortex [20]. Our whole animal experimental approach may be useful in the study of drug dependence. The in vivo encephalography animal model offers opportunity to assess the baseline activity in the cortical areas before exposures to drugs of addiction occur. A similar approach would not be permitted in human subjects for ethical and legal reasons.
