Three highly correlated (i.e., in high linkage disequilibrium; r2 =1.0; D-prime=1.0 based on hg19 1000 Genomes from the CEU sample) intronic SNPs (rs10456907, rs13214667, rs2252790) located within DSE (dermatan sulfate epimerase) on 6q22 were associated with fast beta EEG at a genome wide significant level (p<5×10−8). All variants associated with beta EEG at p <5×10−7 are detailed in Table 1 and depicted in Figures 1 and 2. Conditional analyses, and the high degree of linkage disequilibrium observed among the most significant SNPs (Figure 2), suggest that a single genome-wide signal is implicated. The most significant SNP was rs2252790 (p<2.6×10−8; MAF: 0.36; β: 0.135; Table 1). GWAS results adjusted for DSM-V AUD severity (i.e., GWAS model included DSM-V AUD severity as a covariate) yielded similar results as the primary analyses: intronic DSE variant rs2252790 remained the most significantly associated SNP. However, p-values were slightly less robust (Supplemental Table 1) with only one of three DSE variants remaining genome-wide significant (rs2252790). Three additional sub-threshold (5×10−7>p>5×10−8; Table 1) signals were also detected, including a signal on the long arm of Chromosome 3 (3q11.2;
