Chunk #16 — MATERIALS AND METHODS — Statistical model — QuantiSNP: an Objective Bayes Hidden-Markov Model — Objective learning, expectation maximization(EM) and the Viterbi algorithm

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QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data.

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Given the setting of the hyperparameters, we then use an EM algorithm to find maximum marginal a posteriori estimates for the parameters of the emission distributions. 10