Many of the proteins that demonstrated the greatest differential expression were related to metabolic processes such as phosphoglycerate mutase 2, GDP-D-glucose phosphorylase, mitochondrial NAD- and NADP-dependent malic enzyme, and mitochondrial isobutyryl-CoA dehydrogenase. Of the 390 proteins submitted for interaction analysis in String-db, 376 edges versus an expected number of 239 edges were discovered (Figure 3; enrichment p=2.22×10−16). We identified 37 hub proteins in this highly enriched differential protein expression network (See Supplementary Files for full details on hub proteins for network of differentially expressed proteins). The top five are presented in Table 4 and are highlighted in orange text in Figure 3. Of these five hub proteins, serotransferrin exhibited the greatest degrees of interaction while synaptobrevin homolog Ykt6 displayed the greatest MCC. The assessment of enriched GO terms, KEGG pathways, and Reactome pathways revealed 485 BP, 103 MF, 148 CC, 31 KEGG pathways, and 37 Reactome pathways that were found to be enriched in the network of differentially expressed proteins (See Supplementary File “Enrichment.Hubs_Proteomic” for full details on significantly enriched GO terms network of differentially expressed proteins). The synapse CC
