31 KEGG pathways, and 37 Reactome pathways that were found to be enriched in the network of differentially expressed proteins (See Supplementary File “Enrichment.Hubs_Proteomic” for full details on significantly enriched GO terms network of differentially expressed proteins). The synapse CC (highlighted in green, Figure 3), mitochondrial CC, and metabolic-related BPs were particularly prominent. Additionally, the KEGG metabolic pathway (highlighted in yellow, Figure 3) and numerous other metabolic-related KEGG and Reactome pathways including the citric acid (TCA) cycle and respiratory electron transport, pyruvate metabolism, and citric acid (TCA) cycle, carbon metabolism, and valine, leucine and isoleucine degradation were among the top pathways found to be particularly enriched in this differential protein expression network (See Supplementary Dataset for full details on GO and pathways enrichment).
