Phosphorylation is an important regulator of many molecular pathways and processes, which could potentially be an additional contribution to the divergent endophenotypes in HAP and LAP mice; therefore, phosphopeptide enrichment and quantitation across the DS was performed. A total of 7,289 phosphopeptide groups were quantified with 521 phosphopeptides (from 345 unique proteins) differentially expressed between lines (p<0.05). Table 5 identifies proteins of the top 20 phosphopeptides with the greatest differential expression in HAP relative to LAP mice.
