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Chunk #47 — Methods — Follow-Up in Independent GIANT Consortium Samples (GIANT Stage 2) — Studies and phenotypes

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Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
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For our own Stage 2 analysis, we sought follow-up samples from two independent routes: we included studies with pre-existing GWAS in-silico data (stage 2a) as well as de novo genotyping (stage 2b) comprising 27 cohorts for WC and 21 cohorts for WHR. Among these stage 2 studies, 18 studies were also able to provide data on BMI, weight, and height. All individuals included in stage 2 studies were of European ancestry and provided informed consent. All studies were approved by the local ethics committees. Study-specific information on study design and participants, phenotype means, and experimental detail for all stage 2 studies are included in Tables S3, S4, S5.