In contrast, there were several common changes between protein levels (McBride et al., 2009) in the ACB-shell of P, produced by repeated i.p. injections of 1 g/kg ethanol, and gene expression in the present study (Supplemental Table A). Increased protein levels for Dctn2, Gnai1, Gnai2, Flot1, Snap25 and Phb2 were observed in the ACB-shell of P rats treated with ethanol, whereas ethanol drinking under scheduled access conditions increased expression of genes for Dctn1, Gnao, Flot1, Snap29 and Phb. The increased expression of Dctn (dynactin), Flot (flotillin) and Snap (Synaptosomal associated protein) suggests increased synaptic function (Frick et al., 2007; Kwinter et al., 2009; Pan et al., 2005; Swanwick et al., 2009) in the ethanol group, whereas the higher expression levels of Gna (guanine nucleotide binding protein) and Phb (prohibitin) may indicate enhanced G-protein coupled intracellular signaling and mitochondrial functioning (Merkwirth and Langer, 2009), respectively.
