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Chunk #53 — Discussion

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Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking.
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Kerns et al. (2005) reported on ethanol-responsive genes in 3 brains regions (including the ACB) of C57BL/6J and DBA/2J mice following a single i.p. injection of ethanol. Comparison of the ethanol-responsive genes observed in the ACB of the C57 mice with the ethanol-responsive genes observed in the ACB-shell of P rats in the present study indicated only 5 genes in common, i.e., Psmb6, Myo5a, Mtmr7, Flot1 and Calm3, all of which had higher expression levels in the ethanol group. These results suggest that changes in these genes may be associated with exposure to ethanol.