DAB1 interacts with and participates in signaling from several cell adhesion molecules. DAB1 has long been identified with signaling through the cell adhesion molecule reelin in ways that alter formation and maintenance of neuronal processes [180]. More recent evidence also supports roles for DAB1 in signaling through other cell adhesion/cell regulatory mechanisms, including those that utilize the amyloid precursor protein cell adhesion molecule [181]. DAB1 expression in many brain neurons includes those in hippocampus and mid to deep cerebral cortical layers [172] (http://brain-map.org). Mice with DAB1 disruption display substantial alterations in cerebral cortical development accompanied by gross motor and other behavioral phenotypes [182].
