The estimated average causal mediation effects (ACME) of rs73050610 through the positive and negative first time sensations were 0.0213 (P = 0.70) (a positive coefficient from the mediation analysis means that the hazard is decreased. Refer to the Appendix S1 for the details of the mediation analyses) and −0.0291 (P = 0.77), respectively, suggesting that the effect of rs73050610 is not mediated through the positive or negative first time sensations.
