The top five SNPs for the transition from the age at the first cigarette to the age of daily smoking (rapid vs. slow transition) are shown in Table 3. None of the SNPs exceeded or approached the genome‐wide significance threshold. Manhattan and Q–Q plots are presented in Figure S4. The Q–Q plots show deflated P‐values indicating lack of sufficient statistical power, likely due to the limited sample sizes for an association analysis with a binary variable. We did not pursue follow‐up analyses or attempt replication for this transition.
