The top five SNPs for the transition from daily smoking to heaviest smoking are presented in Table 3. In the time‐to‐event analysis rs11031684 on 11p13 showed genome‐wide significant association (P = 1.29e‐08) (Fig. S5, Table 3) with an HR of 1.46, suggesting that the minor allele accelerates the progression to tolerance. This SNP is located in a pseudogene RP1‐65P5.1, and is flanked by RCN1 and WT1 within a distance of approximately 150 kb. A regional plot of the 11p13 locus is shown in Figure S6. In an analysis conditioned on rs11031684, no residual genome‐wide significant signal remained, suggesting that there is only one independent signal in this locus. In a follow‐up analysis additionally adjusted for age of daily smoking, CPD, and max CPD, rs2304808 residing in FUBP3 on 9q34.12 showed genome‐wide significant association (P = 3.81e‐08) (Fig. S7, Table 3) with an HR of 1.31, suggesting that carriers of the minor allele progress more quickly to tolerance. A regional plot of the 9q34.12 locus is shown in Figure S8. In an analysis conditioned on rs2304808, no residual genome‐wide significant signal
