approved by local human subjects committees. Genotype data are from the Affymetrix Genome-Wide Human SNP Array 6.0 that contains 906,000 single nucleotide polymorphisms (SNPs) and more than 946,000 probes for the detection of copy number variants. The genotype data were processed for quality control, including call rate, concordance rates for blinded and unblinded duplicates, and sex discrepancy, leaving 871,309 unflagged SNPs with a genotyping rate of 99.8% and 3586 HA women used in the current analysis. Genotype Imputation was carried out with MaCH. For imputation in HA samples, we used reference panel of HapMap III CEU + MEX (Mexican ancestry in Los Angeles, California) + YRI samples for a total of 1,387,466 SNPs (MAF > 1%), of which 1,368,178 SNPs met the quality threshold of r2 > 0.3 (Reiner et al., 2012).
