The WHI is a long-term health study following 161,808 postmenopausal women aged 50-79 years old who were recruited from 1993 through 1998 from 40 clinical centers throughout the United States (Hays et al., 2003). Ten of the 40 WHI clinical centers with expertise and access to specific minority groups (American Indian, black, Asian American or Pacific Islander, and Hispanic) were selected to serve as minority recruitment sites. Clinical information was collected by self-report and physical examination. A total of 5,469 self-identified Hispanic Americans (HA) were consented to genetic research and were eligible for WHI-SHARe. Due to budget constraints, we randomly selected a subsample of 3,642 (66.6%) HA women. DNA was extracted by the Specimen Processing Laboratory at the Fred Hutchinson Cancer Research Center from specimens that were collected at the time of enrollment. All participants provided written informed consent as approved by local human subjects committees. Genotype data are from the Affymetrix Genome-Wide Human SNP Array 6.0 that contains 906,000 single nucleotide polymorphisms (SNPs) and more than 946,000 probes for the detection of copy number variants. The genotype data were
