HCHS/SOL analyses followed the standards developed by the HCHS/SOL Genetic Analysis Center and reported in Conomos et al. (2016); Sofer et al. (2016). Table S1 in the Supplementary Material summarizes the information about each of these GWASs, including sample sizes, specific covariates, trait transformations, and imputation reference panels. In brief, analyses used mixed models with variance components due to genetic relatedness, household, and block unit sharing, and were adjusted for sex, age, log-transformed sampling weights (to prevent potential selection bias due to the study design), and the first five principal components reflecting ancestry (to control for population stratification). Samples sizes ranged from 11,809 to 12,705. GWASs for blood count traits in the HCHS/SOL were reported in Schick et al. (2016); Hodonsky et al. (2017); Jain et al. (2017), and GWASs for blood pressure (BP) traits were reported in Sofer et al. (2017b).
