The HCHS/SOL is a community-based cohort study following 16,415 self-identified Hispanic/Latino participants with initial visits between 2008 and 2011 (Sorlie et al., 2010). Participants were recruited into the study in four field centers (Chicago, IL, San Diego, CA, Bronx, NY, and Miami, FL) via a two-stage sampling scheme, by which community block units were first sampled, followed by households within the block units. Some or all household members were recruited. The sampling probabilities were set preferentially towards sampling Hispanics/Latinos (LaVange et al., 2010). In total, 12,803 study participants consented to genetic studies. Henceforth, we focus on this subset when describing the HCHS/SOL population. The HCHS/SOL participants are very diverse, and usually self-identify as belonging to one of six background groups: Central American, Cuban, Dominican, Mexican, Puerto Rican and South American. Genotyping, imputation, and quality control in the HCHS/SOL have been described in Conomos et al. (2016).
