Given that the CC is the most commonly injured white matter structure after traumatic axonal injury,4,23,50,51 and compromise to the integrity of the CC results in reduced interhemispheric functional connectivity among other clinical populations, it stands that patients with TAI should demonstrate reduced functional connectivity as well. In deed, the interhemispheric connectivity results in this study are commensurate with findings among other clinical populations, as patients with TAI demonstrated significantly reduced interhemispheric functional connectivity in bilateral hippocampi and anterior cingulate relative to healthy controls. The results are consistent with a prior case study MacDonald et al. (2008)52 that demonstrated compromised hippocampal connectivity in a single patient who suffered a TBI. To our knowledge, this investigation is the first to examine functional connectivity differences between a group of patients with TAI and healthy controls.
