Johnston et al. (2008)49 demonstrated dramatic reductions in interhemispheric functional connectivity of various functional systems after a complete callosotomy, while intrahemispheric connectivity was relatively preserved. These results implicate the CC as having a significant role in the degree of interhemispheric functional connectivity observed using fMRI, and suggest investigating the influence of corpus callosum damage in functional connectivity among other clinical populations with axonal damage.
