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Chunk #53 — Methods — Psychiatric omnilocus prioritization score

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Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
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We used the gene prioritization method PsyOPS26 to rank genes within genome-wide significant loci. This supervised approach integrates biological annotations on mutational intolerance, brain-specific expression and involvement in neurodevelopmental disorder for genes within significant loci. Genes with the top PsyOPS score within each locus were used for further gene prioritization (Gene prioritization). In the instance where two genes in the same locus had the same PsyOPS score, the gene nearest the index SNP was prioritized.