We performed a PWAS using protein expression data from human brain samples. Human brain proteome reference weight data were obtained using the Religious Orders Study and Rush Memory and Aging Project (ROS/MAP) and the Banner Sun Health Research Institute (Banner) study. The ROS/MAP proteomes were generated from the dlPFC of 376 participants of European ancestry and included 1,476 proteins with significant SNP-based heritability (P < 0.01). The Banner PWAS weights were generated from 152 individuals of European ancestry and included 1,147 proteins with significant SNP-based heritability. The PWAS was performed using the TWAS FUSION software20 with linkage disequilibrium reference information from the 1000 Genomes Project Phase 3 (ref. 95). We corrected for multiple testing using Bonferroni correction.
