We created a list of prioritized genes using both gene-based tests and colocalization–HEIDI filters. Results from each gene-based test were first restricted to protein-coding genes with unique gene identifiers based on the release from GENCODE (version 40) for hg19. The following criteria were then used to prioritize genes: (1) a significant (Bonferroni-corrected) association from at least two gene-based tests (mBAT-combo, TWAS FUSION, SMR or PsyOPS) and (2) evidence of colocalization (COLOC PP4 > 0.8) and/or significant SMR association with HEIDI P > 0.05. Joint–conditional tests of association and significant PWAS associations were used as ancillary approaches to further annotate the prioritized gene list.
