S-PrediXcan identified a positive correlation (p < 1.07 × 10−6) between AUDIT total score and the predicted expression of 26 genes across multiple brain tissues (full results are presented in Supplementary Table 18), including MAPT (cerebellum), FUT2 (caudate and nucleus accumbens), and CRHR1-IT1 (putamen, cerebellum, hippocampus, anterior cingulate cortex). SNPs in the region of MAPT and FUT2 were associated with AUDIT total score in the GWAS. MAPT (cerebellum), FUT2 (nucleus accumbens) and CRHR1-IT1 (caudate, cortex, nucleus accumbens, hypothalamus, hippocampus) were also associated with AUDIT-C (Supplementary Tables 19). S-PrediXcan for AUDIT-C and AUDIT-P (Supplementary Table 20) revealed that lower predicted RFC1 expression in the cerebellum and hemisphere, respectively, was associated with higher scores on both AUDIT-C (p = 7.84 × 10−7) and AUDIT-P (p = 1.54 × 10−6).
