Gene-based (MAGMA) analyses for the AUDIT-C and AUDIT-P subsets (Supplementary Figures 16 and 17, respectively) revealed evidence of overlap (Supplementary Figure 18, Supplementary Table 17). Two genes (KLB, CADM2) were associated with all 3 AUDIT traits (AUDIT total score, AUDIT-C, and AUDIT-P). There was considerable overlap between AUDIT total score and AUDIT-C, with 21 overlapping genes associated at the gene-based level. Only one gene, DRD2, was associated with both AUDIT total score and AUDIT-P.
