Bookstein et al. used novel shape-based CC morphology representations and found that alcohol-exposed subjects showed greater CC shape variability compared to matched controls. This shape-based analytical technique offers the advantage of overcoming the problem of spatial correction required for microcephaly, a common feature of FASD152. These studies demonstrate a differential sensitivity of certain CC sections to PEA. Additionally, it was found that “thick” CC (blunted anterior CC portion with less projection into the frontal regions) correlated with poorer executive functioning, perhaps owing to impaired connectivity of the WM tracts in the anterior CC to the brain regions involved in executive functions, while “thin” CC was related to motor deficits, probably because in this case, the connecting tracts within the CC may be less efficient in relaying information to motor centers153.
