In a gene-set analysis of the targets of individual drugs (from the Drug-Gene Interaction Database DGIdb v.239 and the Psychoactive Drug Screening Database Ki DB40), the targets of the calcium channel blockers mibefradil and nisoldipine were significantly enriched (Supplementary Table 7). Grouping drugs according to their Anatomical Therapeutic Chemical (ATC) classes41, there was significant enrichment in the targets of four broad drug classes (Supplementary Table 8): psycholeptics (drugs with a calming effect on behavior) (especially hypnotics and sedatives, antipsychotics and anxiolytics), calcium channel blockers, antiepileptics, and (general) anesthetics (Supplementary Table 8).
