Genome-wide analyses using MAGMA37 indicated significant enrichment of BD associations in 161 genes (Supplementary Table 4) and 4 gene sets related to synaptic signaling (Supplementary Table 5). The BD association signal was enriched amongst genes expressed in different brain tissues (Supplementary Table 6), especially genes with high specificity of gene expression in neurons (both excitatory and inhibitory) versus other cell types, within cortical and subcortical brain regions in mice (Supplementary Fig. 2)38. In human brain samples, signal enrichment was also observed in hippocampal pyramidal neurons and interneurons of the prefrontal cortex and hippocampus, compared with other cell types (Supplementary Fig. 2).
