GWS only in the trans-population meta-analysis, the results of which were driven largely by the findings in EAs, who comprised 73.5% of the total MVP sample.Table 1Genome-wide significant associations for AUDIT-C in the trans-population meta-analysisrsIDChr:posaA1/A2GenebEAFNZ-scoreP_EAP_AAP_LAP_EAAP_SAAEffectP_ metars12603262:27730940C/T GCKR c 0.652270,2268.221.74 × 10−160.1100.0670.9870.739+++++2.04 × 10−16rs26836162:58035555A/G VRK2 d 0.624211,3996.221.80 × 10−9NA0.0600.487NA+?+−?4.95 × 10−10rs126399404:39420981A/G KLB c 0.613194,7615.933.45 × 10−9NANA0.626NA+??+?3.06 × 10−9rs12299844:100239319C/T ADH1B c 0.970272,35824.564.83 × 10−1021.31 × 10−194.40 × 10−169.05 × 10−3NA++++?3.62 × 10−133rs1427830624:100270960D/I ADH1C c 0.345271,4449.822.04 × 10−144.75 × 10−74.90 × 10−40.0190.779+++++9.50 × 10−23rs131073254:103188709C/T SLC39A8 c 0.937270,24811.451.43 × 10−251.07 × 10−42.23 × 10−3NANA+++??2.24 × 10−30rs44238564:150984857T/C DCLK2 d 0.796212,4445.663.60 × 10−8NA0.2890.5740.144+?+++1.48 × 10−8rs29618165:50443691A/C ISL1 d 0.683260,8285.741.24 × 10−70.0210.6410.9320.137+++++9.75 × 10−9rs48411328:9183596A/G PPP1R3B d 0.101271,192−5.512.75 × 10−66.59 × 10−30.226NA0.148−−−?+3.62 × 10−8rs6203340816:53827962A/G FTO c 0.678270,0679.082.20 × 10−154.78 × 10−50.2290.1770.027+++++1.11 × 10−19rs990251217:47094274C/G IGF2BP1 c 0.664207,229−5.813.81 × 10−8NA0.0550.782NA−?−−?6.24 × 10−9rs14299768617:79419159D/I BAHCC1 c 0.384211,3145.841.77 × 10−9NA0.9440.4340.840+?−+−5.39 × 10−9rs7572334822:41420679T/G RBX1 d 0.736269,7855.712.97 × 10−70.0630.0720.5360.579+++++1.11 × 10−8The loci shown represent completely independent signals after conditioning analysesA1 effect allele, A2 other allele, EAF effective allele frequency, EA European American, AA African American, LA Latino American, EAA East Asian American, SAA South Asian AmericanaHuman Genome hg19 assemblybGene nearest to the lead SNPcProtein-coding gene contains the lead SNPdProtein-coding gene nearest to the lead SNP
