the gene. Bradley et al (2008) identified a three single nucleotide polymorphism (SNP) haplotype (rs7209436, rs110402, rs242924), commonly known at the TAT haplotype, within this block that was protective against major depression in both African Americans and Caucasians who had experienced significant childhood trauma (Bradley et al., 2008). Kranzler et al. (2011) found that the TAT haplotype interacted with adverse childhood experiences to predict depression in African American women; however, no genotype or gene × environment (G × E) effects were found for alcoholism risk in this sample (Kranzler et al., 2011b). It appears that rs110402 is a tag SNP for this haplotype. Treutlein et al. (2006) examined the association between 14 CRHR1 haplotype tagging SNPs (tag SNPs) and alcohol use in two independent samples, one comprised of adolescents and one of adult drinkers (Treutlein et al., 2006). This study implicated two SNPs (rs242938 and rs1876831), located distal to haplotype block 1, with alcohol use phenotypes in both samples. A follow-up study of the adolescent sample reported an interaction between these two markers and measures of negative life events as predictors of the progression from heavy drinking to alcohol use disorders (Blomeyer et al., 2008). Nelson and colleagues (2009) examined
