follow-up study of the adolescent sample reported an interaction between these two markers and measures of negative life events as predictors of the progression from heavy drinking to alcohol use disorders (Blomeyer et al., 2008). Nelson and colleagues (2009) examined the interaction between CRHR1 genotype and childhood sexual abuse as predictors of heavy drinking and AD in a large Caucasian sample (n = 1,128). Results revealed a significant G × E effect for alcohol consumption and alcoholism risk, such that the haplotype comprising the aforementioned SNPs, rs242938 and rs1876831, had a protective moderating effect (Nelson et al., 2009). However, the specific interaction of adult trauma exposure with CRHR1 polymorphisms as a risk factor for alcoholism has not yet been explored.
