Enrichment and concordance of drug-related signatures from Fromer, et al.9 in Rhesus macaque treated with clozapine (N = 9) or haloperidol (N = 17), compared to untreated monkeys (N = 8) (Table 3). For the drugs tested, the number of human ortholog genes affected is listed, along with nominal p-value for enrichment of the gene signature in CMC differential expression data. Number of genes with concordant direction of effect between the gene signature in Fromer, et al.9, along with one-sided enrichment and depletion concordance p-values.Table 3Differential expression of RNA-seq data from macaque drug response trail.DrugSamples(drug/placebo)Genes(n)Enrichment(p-value)Directional ConcordancenEnrichmentDepletionClozapine8/9310.32220.01250.9875Haloperidol8/172371 × 10−935>0.9999<0.0001
