Dysregulation of gene expression is of primary interest in understanding the molecular mechanisms of schizophrenia biology9. This CommonMind Consortium resource has RNA-seq data from postmortem brains from 351 schizophrenia cases and 500 controls. Researchers can perform differential expression analysis to identify genes whose expression differs significantly between cases and controls53. The 4 cohorts can be used to evaluate how well signals from one cohort replicate in an independent cohort. A meta-analysis can be performed by analyzing each cohort separately combining the results of the statistical test, or a mega-analysis can be performed by combining all cohorts into a single analysis.
