The role of epigenetic variation and in particular the variation in chromatin accessibility between schizophrenia cases and controls is of particular interest for its role in mediating downstream gene expression21. This resource includes ATAC-seq data from 126 schizophrenia cases and 127 controls. Researchers can perform statistical analysis of differential chromatin accessibility between cases and controls. These results can then be compared to the differential analysis of gene expression to examine the shared and unique components of these assays. Moreover, the chromatin accessibility data can be directly integrated with gene expression data where both assays were performed on the same samples.
