z-test. P-values for the genetic correlations calculated by testing whether rG was significantly different from zero using a two-sided z-test. P-values in the heritability enrichment analysis were calculated using a one-sided test and tested whether there the estimate of enrichment was significantly different from zero using jackknife standard errors. P-values for genes and gene-sets were calculated using a competitive one-sided test to examine the whether the gene or gene-set was significantly different to that expected from random chance.
