Chunk #14 — Results — Kal7 is expressed in the major neuronal cell types in nucleus accumbens and dorsal striatum — Usage of promoters encoding full-length mouse Kalrn is region-specific
exons, which are separated by large introns, encode unique N-termini that are five to 38 amino acids long. Exons 2 to 5 (35 kb) encode the common Sec14p-like domain while exons 5 through 22 (150 kb) encode the nine spectrin-like repeats. Exons 24 through 32 encode the first GEF domain. The 3'-terminal exon unique to Kal7 and ΔKal7 is flanked by two large introns while the exons encoding the second GEF domain (exons 39-47), which is present in Kal9 and Kal12, and the Ser/Thr kinase domain (exons 58-60), which is unique to Kal12, are densely clustered (Figure 2).
