Osterndorff-Kahanek et al. (2015) reported that in the prefrontal cortex of CIE-exposed C57BL/6J mice, neuron- and astrocyte-related genes were differentially expressed. We saw no enrichment of astrocyte genes, but did see enrichment of neuron-related differentially expressed genes in the mPFC, vHip, DRN and PAG of these animals. A study by Meinhardt et al. (2013) of Wistar rats after 3 weeks of recovery from chronic intermittent exposure to ethanol vapor (CIE) reported decreased expression of genes related to glutamtergic neurons in the mPFC. At 3h post-exposure we saw increases in 7 of the genes related to glutamate transmission, Egr4, Stx1a, Lmo4, Nrgn, Nr4a1 and Zfp238.
