Here, we discuss several of the cell adhesion related genes that have been identified in multiple sets of replicated genome wide association studies (Table I). Monte Carlo trials that seek to establish the level of significance of identification of these genes in multiple datasets establish levels for this convergent identification that range from 0.006 to < 0.00001. We also discuss follow up data for two cell adhesion molecule genes, NrCAM and NRXN3, which were initially identified by lower density genome wide association studies [10, 11]. Results from these two loci provide examples of the ways in which initial identification in genome wide association studies can lead to subsequent identification of specific haplotypes that alter levels of expression of the gene or levels of expression of a specific set of splice variants.
