CAMs with the strongest levels of cumulative support: One of the cell adhesion molecules that achieves the most striking nominal p values in these analyses is an “atypical” member of the cadherin gene family, CDH13. Cadherin 13 is a glycophosphoinositol (GPI)-anchored cell adhesion molecule. CDH13 is expressed in neurons in brain regions that are likely to play roles in addiction, including hippocampus, frontal cortex, and ventral midbrain [171]. CDH13 can inhibit neurite extension from select neuron populations [161, 171] and activate a number of signaling pathways [164–167]. It is thus a strong candidate for roles in brain mechanisms important for both developing and quitting addictions.
